HomeProjectsBiomedical Sciences and Healthcare TechnologiesA Novel Virus-Free Anticancer Gene Therapy

A Novel Virus-Free Anticancer Gene Therapy

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Gene therapy conventionally utilizes virus to correct diseased genes for eliminating cancer, but safety risks and off-target effects of viral method largely limit their clinical translation.

Therefore, CUHK team combined RNA interference technology and ultrasound microbubble system to form a novel virus-free gene therapy. The invention specifically delivers gene silencing particles into tumor without using any virus. It can serve as a rapid evaluating platform for therapeutic efficiency of new gene targets preclinically, as well as development to be a safe anticancer therapy clinically.

Conventional method Method in This Project
Safety
  • Delivery by virus
  • Permanent change
  • Virus-free
  • Reversible
Flexibility
  • Genomic level
  • Cannot target post-transcriptional level
  • mRNA level
  • Can design for any new gene isoforms
Precision
  • Relatively low
  • Systemic diffuse
  • Affect all tissues
  • High
  • Tissue-specific
  • Release in tumour
In our invention, the gene-silencing particles are specifically delivered to tumor by ultrasound microbubble system.
Our new method effectively stops the growth of human lung cancer by largely enhancing the anticancer immunity (iNOS+ F4/80) in tumor.
Our method (right), the gene-silencing plasmids (green) can be specifically delivered to tumor, avoiding off-target side effects of gene therapy.

CE’s Reception for Awardees of International Exhibition of Inventions of Geneva 2021

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