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Single Cell Population Gene Expression Biomarkers: As Emerging Routine Blood Tests

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Project Quick Facts

Principal Investigator

  • Prof. TANG Leung Sang Nelson

    Department of Chemical Pathology

  • Award

    Bronze Medal, 47th International Exhibition of Inventions Geneva

This is an assay to determine gene expression level of a specified cell-type subpopulation (e.g. T cell) by direct analysis of a whole blood sample without the need of prior separation of the component cell populations. The assay can be performed by real time qPCR, microarray or RNA-seq platforms. Applications are huge as it enables gene expression tests to be used in routine medical setting.

Uniqueness and Competitive Advantages:

  • Proof of concept with Direct LS-TA (leukocyte subtype-transcript abundance) assay for T cell specific gene expression in whole blood samples
  • Can be used in qPCR platform with as little as 2 gene markers
  • Avoid labour-intensive cell separation procedures not feasible in hospital service laboratory
  • Applications in infectious disease and immunological diagnosis, e.g. renal transplant patients on immunosuppressant therapy

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