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This is an assay to determine gene expression level of a specified cell-type subpopulation (e.g. T cell) by direct analysis of a whole blood sample without the need of prior separation of the component cell populations. The assay can be performed by real time qPCR, microarray or RNA-seq platforms. Applications are huge as it enables gene expression tests to be used in routine medical setting.
Uniqueness and Competitive Advantages:
- Proof of concept with Direct LS-TA (leukocyte subtype-transcript abundance) assay for T cell specific gene expression in whole blood samples
- Can be used in qPCR platform with as little as 2 gene markers
- Avoid labour-intensive cell separation procedures not feasible in hospital service laboratory
- Applications in infectious disease and immunological diagnosis, e.g. renal transplant patients on immunosuppressant therapy