HomeProjectsBiomedical Sciences and Healthcare TechnologiesNovel Injectable Scaffold for Treating Osteoporotic Bone Defects

Novel Injectable Scaffold for Treating Osteoporotic Bone Defects

Project Quick Facts

Principal Investigator

  • Prof. NGAI To

    Department of Chemistry

  • Funding Sources

    Research Grants Council

    Health Bureau

    Innovation and Technology Commission

  • Collaboration

    O-Spheres Limited

  • Patent

    1 USA patent application pending

Existing calcium-based cement augmentation products suffer from the excessively slow degradation, which may impede bone regeneration. Hence, the team has developed a novel hierarchical porous Magnesium oxychloride cement foam (MOCF)-derived scaffold with a more appropriate bio-resorption kinetic and superior bioactivity for bone defect repair. The developed MOCF shows excellent handling performance in the paste state, while exhibiting sufficient load-bearing capacity after solidification. In comparison with the traditional calcium-based bone cement, the MOCF scaffold demonstrates a much higher biodegradation tendency and better cell recruitment ability. This advanced MOCF scaffold is anticipated to be competitive for clinical therapies to augment osteoporotic bone regeneration.

Schematic illustration of the fabrication of the MOCF scaffold and its application for treating distal femoral defect in an ovariectomy (OVX)-induced osteoporotic rat model

Uniqueness and Competitive Advantages:

  • Higher biodegradation tendency
  • Better cell recruitment ability
  • Enhancing in vitro and in vivo osteogenesis
  • Better osseointegration capacity
Demonstration of the cohesion performance of the MOCF paste

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