Existing calcium-based cement augmentation products suffer from the excessively slow degradation, which may impede bone regeneration. Hence, the team has developed a novel hierarchical porous Magnesium oxychloride cement foam (MOCF)-derived scaffold with a more appropriate bio-resorption kinetic and superior bioactivity for bone defect repair. The developed MOCF shows excellent handling performance in the paste state, while exhibiting sufficient load-bearing capacity after solidification. In comparison with the traditional calcium-based bone cement, the MOCF scaffold demonstrates a much higher biodegradation tendency and better cell recruitment ability. This advanced MOCF scaffold is anticipated to be competitive for clinical therapies to augment osteoporotic bone regeneration.
Uniqueness and Competitive Advantages:
- Higher biodegradation tendency
- Better cell recruitment ability
- Enhancing in vitro and in vivo osteogenesis
- Better osseointegration capacity