HomeProjectsBiomedical Sciences and Healthcare TechnologiesUltrafast Tissue Scaffold 3D Printing and Imaging Platform for Biomedical Applications

Ultrafast Tissue Scaffold 3D Printing and Imaging Platform for Biomedical Applications

Project Quick Facts

Principal Investigator

  • Prof. ZHOU Renjie

    Department of Biomedical Engineering

  • Prof. CHEN Shih Chi

    Department of Mechanical and Automation Engineering

  • Funding Sources

    Innovation and Technology Commission

  • Collaboration

    Massachusetts Institute of Technology

  • Patent

    1 US patent application

    1 China patent application

  • Award

    2018 R&D 100 Awards – Digital Holography-based 3-D Nano-Builder

This project aims to develop next-generation ultrafast 3D bio-imaging and lithographic microfabrication technologies, i.e., an integrated tissue scaffold 3D printing and imaging platform. We will utilize a high throughput tomographic phase microscopy (TPM) for monitoring scaffold formation and tissue growth and develop super-resolution imaging for monitoring cell redox in vivo.

(a) Optical configuration of structured light illumination (SLI) temporal focusing system (b) Principle of DMD-based temporal focusing configuration.
(c) Experimental design of the TPM system

Uniqueness and Competitive Advantages:

  • The cost of 3D printing platform is low, but have a high resolution.
  • It combines high throughput and spatial resolution.
  • Our tomographic phase microscopy (TPM) is capable of ultra-fast 3D imaging, which can meet the 3D printing and in situ monitoring demand.
  • Our integrated platform can perform multimodal imaging, including multi-photon temporal focusing microscopy, tomographic phase microscopy, fluorescence lifetime imaging and 3D structured illumination microscopy. These modalities together can offer a more complete information of the biological structures and their physiological processes.
Ultrafast super-resolution 3D imaging of tissue samples

Do you like our project?