To address the difficulties in early diagnosis and challenges of quantitative evaluation of neurodegenerative Parkinson’s disease, this project aims to reveal the degeneration mechanism of pathological gait by establishing a kinetic model of human walking lower limbs. An adaptive gait characterization technique for neurodegenerative Parkinson’s disease will be proposed, and the co-featured space of multi-source parameters can be obtained. The project will use myoelectric signals, kinematic and dynamic parameters to form a comprehensive quantitative evaluation index of Parkinson’s disease gait. The final purpose is to develop a wearable health monitoring and intelligent diagnostic system to provide Parkinson’s patients with convenient and accurate daily monitoring and early diagnosis services.